Our research papers, reviews and invited scientific blog on our drug delivery platform technology
Crossing the Blood-Brain Barrier with Nanoligand Drug Carriers Self-assembled from a Phage Display Peptide
In a paper published in Nature Communications (October 2019), we show hierarchial forms of a brain-specific phage-derived peptide (herein as NanoLigand Carriers, NLCs) target cerebral endothelial cells through transferrin receptor and the receptor for advanced glycation-end products, cross the blood-brain-barrier and reach neurons and microglial cells.
Phage Mimetic Self-Assemblies Deliver Nucleic Acids to the Brain
The Blood-Brain Barrier (BBB) accounts for the failure of large number of promising neurotherapeutics including nucleic acid therapies. We show that phage mimetic self assemblies Nanocarrier Ligands (NLCs) carry nucleic acid therapeutics to the brain effectively and safely.