PUBLICATIONS

Our research papers, invited scientific blog in Nature Bioengineering Community on our biotechnology platform and an editorial commentary by our co-founders on brain targeting.

For other papers by our scientists visit Other Publications page

Here we show hierarchial forms of a brain-specific phage-derived peptide (herein as NanoLigand Carriers, NLCs) target cerebral endothelial cells through transferrin receptor and the receptor for advanced glycation-end products, cross the blood-brain-barrier and reach neurons and microglial cells.

Wu, L., Ahmadvand, D., Su, J. et al. Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide. Nat Commun 10, 4635 (2019) doi:10.1038/s41467-019-12554-2

Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide

A commentary/editorial on brain targeting by the founders of SMDG in the journal of Therapeutic Delivery 

We show that hierarchical forms of a phage display peptide efficiently target the brain and ferry nucleic acid medicines to neurons and microglia.

Drug delivery to the brain: self-assembled phage mimetics for crossing the blood-brain-barrier

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