In the News and Media
March 20, 2020
SMDG's technology and paper listed as one of the notables of 2019:This was the year that was: brain barriers and brain fluid research in 2019
This editorial highlights advances in brain barrier and brain fluid research published in 2019, as well as addressing current controversies and pressing needs. Topics include recent advances related to: the cerebral endothelium and the neurovascular unit; the choroid plexus, arachnoid membrane; cerebrospinal fluid and the glymphatic hypothesis; the impact of disease states on brain barriers and brain fluids; drug delivery to the brain; and translation of preclinical data to the clinic.
Fluids and Barriers of the CNS
October 16, 2019
New breakthrough can effectively deliver medications into the brain
Scientists have found a way to effectively transport medication into the brain which could lead to improved treatments for neurological and neurodegenerative diseases.
European Pharmaceutical Review
October 15, 2019
Unlocking the Blood-Brain-Barrier: A new simple and innovative way of delivering therapeutics to brain
Scientists have traditionally faced the problem that blood capillaries in the brain are not permeable to many drugs. In fact, the majority of drugs are excluded from the brain by a protective barrier, called the blood-brain-barrier (BBB), and current treatment options are risky and challenging.
Bio New Jersey
October 15, 2019
Unlocking the Blood-Brain-Barrier: A new simple and innovative way of delivering therapeutics to brain
Professor Moein Moghimi, who led the research team, said, "Crossing the blood-brain-barrier has been a major impediment to effectively addressing central nervous system diseases, including brain tumors, and many neurological diseases like Parkinson's, Alzheimer's and Huntington's. This breakthrough, based on more than 10 years of research, has significant implications for crossing the blood-brain-barrier and other biological barriers that have created challenges for drug delivery."
International Business Times
February 5, 2020
Phage mimetic self-assemblies deliver nucleic acids to the brain
The brain is a privileged organ heavily protected by a complex cellular barrier termed the blood–brain barrier (BBB), which selectively excludes most blood-borne substances from entering the brain. The BBB accounts for the failure of a large number of promising neurotherapeutics, including nucleic acid medicines such as RNA interference (siRNA). In the past decade, we have witnessed vested efforts in finding viable strategies for drug delivery to the brain through minimally invasive routes of administration and without compromising the integrity of the BBB. To this end, our own efforts have recently introduced phage mimetics as new types of ’simple-by-design’ and ’safe-by-design’ multifunctional self-assemblies for active targeting of the BBB and ferrying therapeutic molecules such as siRNA to neurons and microglial cells.
Nanomed Zone
October 15, 2019
New Unlocking the Blood-Brain-Barrier: A new simple and innovative way of delivering therapeutics to brain
In a groundbreaking study published October 11 in Nature Communications, an international team of scientists from Newcastle University and Denver-based S M Discovery Group (SMDG) have designed a carrier system that delivers medicines to the brain through intravenous injection.
Denver Cityroom
October 15, 2019
Unlocking the Blood-Brain-Barrier
Professor Moein Moghimi, who led the research team, said, "Crossing the blood-brain-barrier has been a major impediment to effectively addressing central nervous system diseases, including brain tumors, and many neurological diseases like Parkinson's, Alzheimer's and Huntington's. This breakthrough, based on more than 10 years of research, has significant implications for crossing the blood-brain-barrier and other biological barriers that have created challenges for drug delivery."
Dow Theory Letters - Financial Markets
October 15, 2019
Unlocking the Blood-Brain-Barrier: A new simple and innovative way of delivering therapeutics to the brain
In a groundbreaking study published October 11 in Nature Communications, an international team of scientists from Newcastle University and Denver-based S M Discovery Group (SMDG) have designed a carrier system that delivers medicines to the brain through intravenous injection.
Physician Family Media
November 12, 2019
Beyond the Barrier
The blood-brain barrier (BBB) represents a formidable foe for drug delivery scientists, who have experimented with numerous angles of attack. “Over the years, complex design (with poor pharmaceutical attributes), poor target recognition, low frequency of crossing the BBB, and poor ability to subsequently target parenchymal cells (for example, neurons and microglia cells) are among some of the major challenges for achieving drug delivery to the brain,” says Moein Moghimi, Professor of Pharmaceutics and Nanomedicine at Newcastle University.
The Medicine Maker
October 15, 2019
Unlocking the Blood-Brain-Barrier: A new simple and innovative way of delivering therapeutics to the brain
Professor Moein Moghimi, who led the research team, said, "Crossing the blood-brain-barrier has been a major impediment to effectively addressing central nervous system diseases, including brain tumors, and many neurological diseases like Parkinson's, Alzheimer's and Huntington's. This breakthrough, based on more than 10 years of research, has significant implications for crossing the blood-brain-barrier and other biological barriers that have created challenges for drug delivery."
Market Business Insider
October 15, 2019
Unlocking the Blood-Brain-Barrier: A new simple and innovative way of delivering therapeutics to brain
Professor Moghimi and his team engineered small particles using a peptide that can behave like a carrier (like viruses) to the brain and can be packed with drugs for intravenous injection. This allows for minimally invasive and combination drug delivery to the brain.
Finanzen.net Germany
October 15, 2019
Unlocking the Blood-Brain-Barrier: A new simple and innovative way of delivering therapeutics to the brain
In a groundbreaking study published October 11 in Nature Communications, an international team of scientists from Newcastle University and Denver-based S M Discovery Group (SMDG) have designed a carrier system that delivers medicines to the brain through intravenous injection.
Manhattan Week